New Phase I/II Trial Using Multimodal PDT for Advanced, Recurrent Colorectal Cancer
Long a pioneer in innovative treatments for colorectal cancer, Roswell Park Comprehensive Cancer Center is recruiting patients with locally advanced or recurring colorectal cancer for a new trial involving photodynamic therapy, a technology created here in the 1970s.
Photodynamic therapy was first successfully used to treat primary and secondary skin tumors but its use has evolved to effectively treat head and neck cancers, recurring malignancies that did not respond to prior therapies and advanced or recurrent colorectal cancer.
In this trial, which is adjunct to current standard of care, the patient will receive 5-Aminoluvulinic acid (5-ALA), a photosensitizing agent, “allowing for image-guided surgery as well as to amplify and augment the effects of photodynamic therapy on the surgical margins,” explains Anthony Dakwar, MD, FACS, FASCRS, Medical Director of Perioperative Services at Roswell Park.
The trial is currently open and recruiting patients.
Assistant Professor of Oncology Department of Surgical Oncology
Dr. Anthony Dakwar is a fellowship trained Colon and Rectal Surgeon, specializing in treatment of complex colorectal cancers. He takes special interest in treating hereditary and familial colon cancer syndromes, along with Inflammatory ...
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